From Tempelhof airport:

• Underground line U6 headed for Alt Tegel. Alight at Stadtmitte station

From Tegel airport:

• TXL express bus straight from the hotel to Friedrichstrasse

From Bahnhof Zoo railway station:

• Underground line U2 headed for Vinetastr.
• or all "S-Bahn" trains heading eastwards. Alight at Stadtmitte station

S-Bahnhof Friedrichstrasse railway station:

• Change into the U6 underground line headed for Alt-Mariendorf and alight at Stadtmitte station